Work over the first eighteen months of the project has identified metabolomic markers of exposure to pesticides and toxic alcohols. A publication by Prof Thomas's Loughborough group reported identification of the toxic alcohols methanol, ethylene glycol, and 1,3-propandiol, and their metabolites, as well as ethanol in human saliva.
Biological toxins are a heterogeneous group of compounds that share commonalities both with biological and chemical agents. Based on their availability, toxicity, and the lack of medical countermeasures as well as their known history of military research, toxins such as ricin, botulinum neurotoxins, staphylococcal enterotoxins, and saxitoxin are classified as toxins of bioterrorism risk.
The forehead was studied as a possible sampling site for capturing changes in volatile organic compound (VOC) profiles associated with psychological-stress. Skin-VOCs were sampled with a polydimethylsilicone (PDMS)-coupon and the resulting VOCs were recovered and analysed with two-stage thermal desorption gas chromatography-mass spectrometry.
The TOXI-triage project is mentioned in the paper Mapping Emergency Responders’ Current Procedures in the Event of a CBRNe Incident, included in the proceedings of the Healthcare Ergonomics & Patient Safety (HEPS) conference held in Toulouse on the 5-7 October 2016. (pages 432-434)
The terror events in Paris in November, 2015, and elsewhere remind us of the substantial consequences that violent events can have for a population's mental health. Although effective approaches exist for treating these consequences, no systematic attempts have been made to identify populations at risk early on to expeditiously mitigate them. Social media could help identify populations in need during and after disasters.
First Project brochure summarising the TOXI-triage approach to CBRN response and recovery: project headlines, objectives, technologies and research.