Objectives

The main goal for TOXI-triage is to develop and field/trial a new level of medical care and site management during triage within rescue efforts in a CBRN incident.

In order to allows nineteen TOXI-triage consortium partners to focus their efforts distributed in nine different work packages by applying specific, measurable, achievable and realistic objective during project live-cycle following Project Specific objectives have also been defined:

  1. SO1: Accelerated delivery of Situational Awareness. The time to assess a scene can be reduced to under 5 minutes resulting in a significant increase in survival rates and protection of end-users
  2. SO2: Command and Control with secure, dynamic, and seamless communication and with Artificial Intelligence (AI) assisted tools for making decisions (The Integrator). Information providing current levels and movement of agents will be blended with the locations, position, and movement of casualties to assist decision making, communication, and site management through central Command and Control. This also includes automatic logging and archiving of events, measurements, forming records of patient care and tools/algorithms for the semantic web.
  3. SO3: Traceable point-of-care diagnostic tests with integrated casualty tracking. A central concept introduced in TOXI‐triage derives from advanced principles and technology for levels of exposure to all agents in a single procedure. Metabolites of injury from CBRN exposure are available in volatile organic compounds found in breath, respired skin vapours, and saliva (SO5).
  4. SO4: Comprehensive field toolbox of CBRN threats for end-users. Automated guidance to end user at point of need. Useable and effective knowledge about CBRN agents in order to function amid confusion and sensory overload in a poisonous environment is needed for end-users in real time throughout a catastrophic incident. Neither those in Command and Control nor those tending casualties currently have easily digested knowledge spanning such a large topic.
  5. SO5: Protocol for the registration of biomarkers of injury from CBRN poisoning with the European Medicines Agency. Levels of exposure to Agents can be determined through non-invasive measurement of volatile organic substances respired from skin, breath, and saliva. TOXI‐triage will establish a common standard for CBRN rescue and medical care throughout Europe with certain essentials including evidence based medical care, clinic-validated methods, verified measurements, and common procedures.
  6. SO6: Establish a harmonized European framework for ethical and accountable CBRN operations. The methods, messages, and design of TOXI‐triage will guard cultural and personal dignity within the context of rescue.
  7. SO7: Establish a Community of Commerce and deliver a commercial vision. We will seek the commercial scale-up of technology and methods for point-of-care toxicity triage (SO3,SO5). Benefits will be sought in poison treatment centres, as new search and rescue tools, for surveillance of clandestine laboratories, and in the discovery of illegal chemical discharges. These specific objectives follow the SMART concept of being specific, measureable, achievable, realistic and timed and are addressed in nine work packages distributed among nineteen members of the TOXI‐triage consortium.